Vaginal Estrogen gets thumbs up as safe treatment for menopausal dryness

Article by
Anna Mooney.

Good news for post-menopausal women who rely on vaginal estrogens to relieve discomfort - researchers at the University of California at LA have established no raised risk of cancer or other diseases

Women who have gone through menopause and who have been using a vaginal form of estrogen therapy do not have a higher risk of cardiovascular disease and cancer than women who have not been using any type of estrogen.

Among women with an intact uterus, the risks of stroke, invasive breast cancer, colorectal cancer, endometrial cancer and pulmonary embolism/deep vein thrombosis were not significantly different between vaginal estrogen users and nonusers. The risks of coronary heart disease, fracture and premature death were lower in users than non-users. The risks of coronary heart disease, stroke, cancer and pulmonary embolism/deep vein thrombosis for women who had undergone hysterectomies were not significantly different in users of vaginal estrogen compared to nonusers. 

Previous concerns

Randomized trials and other studies have shown that women who take estrogen therapy in the form of a pill may have an increased risk of blood clots, stroke and if the estrogen is used together with progestogen pills, invasive breast cancer. Some women take a vaginal form of estrogen, and it has not been known whether that treatment carries risks similar to the tablet form.   


Clean bill of health

This study, the first to examine potential adverse health effects in users of vaginal estrogen compared with non-users, suggests that vaginal estrogen therapy is a safe treatment for genitourinary symptoms such as burning, discomfort, and pain during intercourse associated with menopause.

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